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Title   소세포폐암의 예후인자 : 이중병기체계의 타당성 분석 ( Prognostic Factor Analysis of Small Cell Lung Cancer: Appropriateness of Two Staging System )
Publicationinfo   1997 Jan; 029(06): 1000-1011.
Key_word   Prognostic factors, Small cell lung cancer
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Abstract   Purpose: The two staging system, which divides the tumors into limited disease(LD) and extensive disease(ED) has been widely accepted as a major prognostic determinant in small cell lung cancer(SCLC). However this system has provoked several controversial issues in defining stage categories, for instance, ipsilateral pleural effusion as LD or ED. Furthermore, identification of favorable subgroups in the same stage has been recognized as an important factor to determine appropriate treatment strategies. In this study, we performed a retrospective analysis in an attempt to resolve the controversial issues about staging and identify the patient group with favorable prognosis based on this two staging system. Materials and Methods: The clinical data of 233 patients with SCLC treated from 1990 to 1996 at Korea Cancer Center Hospital were retrospectively analyzed for this study. All patients were treated with chemotherapy containing cisplatin and/or radiotherapy. The independent prognostic factors for survival were identified by multivariate analysis using Coxs proportional hazards model. Results: Performance status(relative risk of death [RR]:2.89), number of metastasis(RR:2.2), response to treatment(RR:2.2) as well as stage(RR:1.77) were identified as independent prognostic factors for survival in patient with SCLC. The median survival of patients with ipsilateral pleural effusion(13 months) which was categorized as ED was similar to that of patients with contralateral mediastinal or supraclavicular lymph nodes(13.8 months) or other LD patients(13.7 months). This result suggests that ipsilateral pleural effusion should be categorized as LD. In LD, response to treatment was the only independent prognostic (continue...)
저 자   장재진(Jae Jin Jang),김태유(Tae Yoo Kim),이춘택(Choon Taek Lee),남승모(Seung Mo Nam),김재학(Jae Hak Kim),송은정(Eun Jung Song),김성환(Sung Hwan Kim),김봉석(Bong Seok Kim),류백렬(Baek Ryol Ryu),임영혁(Young Hyuk Lim),이진오(Jin Oh Lee),강태웅(Tae Woong Gang),강윤구(Yoon Koo Kang)